6 - 8 weeks
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Inflammatory skin diseases are the most common problem in dermatology. Chemical and physical stimuli trigger a cutaneous response by first inducing the main epidermal cells, keratinocytes, to produce specific mediators that are responsible for the initiation of skin inflammation. When exposed to irritants, pro-inflammatory cytokines are activated via a predictable signaling cascade. This allows detection of inflammatory activation in cell models and 3D human skin models. The test is used to assess new cosmetic ingredients/formulations, providing critical insights into the anti-inflammation potential of the product.
Illustrative diagram showing the activation of pro-inflammatory cytokines by irritants.