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  • Overview

     Skin corrosion is defined as the production of irreversible tissue damage, manifested as visible necrosis of the skin. (UN GHS)    

     Skin irritation is defined as reversible damage to the skin following exposure to a single substance or mixture for up to 4 hours. (UN GHS)   

 Illlustrative diagram of skin irritation/corrosion test.   

In Vitro Skin Irritation/Corrosion: Reconstructed Human Epidermis Test

(OECD Test Guideline 439/431)

Several validated skin models can be used for the irritation and corrosion test. SKINetrate can use your desired skin model or recommend the most suitable model for your testing needs.